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Table 2 Acute toxicity tests in mice by intraperitoneal injection (n = 8)

From: Encapsulation of Aconitine in Self-Assembled Licorice Protein Nanoparticles Reduces the Toxicity In Vivo

Group Dead Time to death (min) Toxic effects
a 0 Normal
b 8 100 ± 15 Gather, eyes close, tremble, convulsions, opisthotonos position
c 0 Gather, eyes close, less active, returned to normal in 3 h
1 0 Normal
2 8 18 ± 5 Gather, eyes close, tremble, convulsions, opisthotonos position
3 8 30 ± 5 Gather, eyes close, tremble, convulsions, opisthotonos position
4 8 50 ± 5 Gather, eyes close, tremble, convulsions, opisthotonos position
5 0 Gather, eyes close, less active, returned to normal in 3 h