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Table 1 Independent variables and levels of experiment design

From: Liquid Crystalline Nanoparticles as an Ophthalmic Delivery System for Tetrandrine: Development, Characterization, and In Vitro and In Vivo Evaluation

Independent variables

Levels

−1.682

−1

0

1

1.682

X 1: amount of TET (mg)

5

6.01

7.5

8.99

10

X 2: amount of GMO (mg)

200

260.81

350

439.19

500

X 3: F127/GMO (%)

9

10.22

12

13.78

15

  1. A three-factor, five-level central composite design was generated to optimize the TET-LCNP preparation. The study design involved investigating the effects of three independent variables, including the amount of TET (X 1), the amount of GMO (X 2), and the F127/GMO ratio (X 3). The dependent variables were the entrapment efficiency (Y 1) and drug loading capacity (Y 2) of the TET-LCNPs
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