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Table 5 Pharmacokinetic parameters of TET in aqueous humor after topical administration in the conscious rabbits (\( \overline{X}\pm \mathrm{S}\mathrm{D}, \) n = 3)

From: Liquid Crystalline Nanoparticles as an Ophthalmic Delivery System for Tetrandrine: Development, Characterization, and In Vitro and In Vivo Evaluation

Preparation	T _max (h)	C _max(μg mL⁻¹)	AUC (μg mL⁻¹ h)	t _1/2 (h)
TET solution	0.50 ± 0.10	0.41 ± 0.03	0.61 ± 0.03	0.85 ± 0.01
TET-LCNPs	0.83 ± 0.10*	0.86 ± 0.03**	1.64 ± 0.07**	1.41 ± 0.10**

T _max time to peak concentration, C _max maximal concentration of TET, AUC area under the curve, t _1/2 half-time
^* p < 0.05 versus TET solution; ^** p < 0.01 versus TET solution

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