Table 3 Examples of marketed liposomal for anesthesia drug and other drugs
Trade name | Nanoparticle platform | Drug | Size | Indication |
|---|---|---|---|---|
Anti-cancer | ||||
Doxil/Caelyx (Janssen) | PEG-liposomes | Doxorubicin | 100 nm | Kaposi’s sarcoma, ovarian cancer, breast cancer, combination with bortezomib in multiple myeloma |
DaunoXome (Galen) | Lipid nanoparticle | Daunorubicin | 45–80 nm | Kaposi’s sarcoma |
DepoCyt (Pacira) | Lipid nanoparticle | Cytarabine | 20 μm | Malignant lymphomatous meningitis |
Marqibo (Talon) | Lipid nanoparticle | Vincristine | 100 nm | Acute lymphoblastic leukemia |
Myocet (Cephalon) | Lipid nanoparticle | Doxorubicin | 80–90 nm | Combination therapy with cyclophosphamide in breast cancer |
Analgesics | ||||
Diprivan (Fresenius Kabi) | Lipid emulsion | Propofol | 180 nm | Anesthesia |
DepoDur (Pacira) | Lipid nanoparticle | Morphine | 17–23 μm | Postsurgical pain |
Exparel (Pacira) | Lipid nanoparticle | Bupivacaine | 24–31 μm | Anesthesia |
Antifungal | ||||
Abelcet (Sigma-Tau) | Lipid drug particles | Amphotericin B | 2–5 μm | Aspergillosis |
AmBisome (Astellas) | Liposome | Amphotericin B | <100 nm | Antifungal, leishmaniasis |