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Fig. 5 | Nanoscale Research Letters

Fig. 5

From: Synthesis, Characterization, and Study of In Vitro Cytotoxicity of ZnO-Fe3O4 Magnetic Composite Nanoparticles in Human Breast Cancer Cell Line (MDA-MB-231) and Mouse Fibroblast (NIH 3T3)

Fig. 5

Dose-response curve of ZnO NPs (a) and MCPs (b) on cancer cell line MDA-MB 231 (Adj. R 2 = 0.91) and cytotoxicity plot ± SD of same agents on noncancerous cell NIH 3T3. Both agents show concentration independent and very less cytotoxicity on NIH 3T3 in comparison to dose-dependent strong response towards cancer cell (MDA-MB-231). This inherent selectivity of ZnO NPs, however, was found to be synergistically enhanced in MCPs with high potency (EC50 31.29 μg/mL for MCPs and 38.44 μg/mL for ZnO only) and significant hill slope (P) 1.21

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