Fig. 5
From: Dendritic Core-Multishell Nanocarriers in Murine Models of Healthy and Atopic Skin
Subcutaneously injected CMS-ICC were localized in the regional lymph nodes, lung, liver, spleen, and kidney of healthy mice without any toxic or other adverse effects. a–t Approx. 16 h after the last subcutaneous injection, CMS-ICC were predominantly found in and between cells of the draining lymph nodes (a, arrows). Furthermore, CMS-ICC were found in the alveolar septa of the lung (e, arrow), intracellularly in cells located within the sinusoids of the liver, consistent with Kupffer cells (i, arrow), throughout the splenic parenchyma both intracellularly and extracellularly (m, arrow), and in the kidney, predominantly localized in the glomeruli (q, arrows).