Fig. 2
From: Biocompatibility of Liposome Nanocarriers in the Rat Inner Ear After Intratympanic Administration
Gadolinium-enhanced MRI of rat inner ear after liposome nanocarrier (LPN) administration. In all animals, nanomaterials were injected onto the medial wall of left middle ear cavity. The positive control was imaged in rats at 2 h post-intravenous injection of Gd-DOTA secondary to transtympanic injection of silver nanoparticles (AgNPs) 5 h in advance (a, b). Dynamic distribution of LPNs in the middle and inner ears was shown in c, d, e, f by transtympanic injection of Gd-DOTA-containing LPN without intravenous administration of Gd-DOTA. The impact of empty LPNs on the biological barrier was shown by MRI at 2 h post-intravenous injection of Gd-DOTA (i.v. Gd-DOTA) in rats receiving transtympanic injection of LPN 5 h in advance (g, h). Am ampullar of posterior semicircular canal, Coch cochlea, EES external ear skin, L left ear, LPN-Mu LPN in the middle ear mucosa, LPN-OC LPN on the ossicular chain (OC), ME-Mu, middle ear mucosa, R right ear, SM scala media, ST scala tympani, SV scala vestibuli, Vest vestibulum, 1H basal higher turn of cochlea, 1L basal lower turn of cochlea, 2H second higher turn of cochlea, 2L second lower turn of cochlea. Scale bar = 5 mm