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Table 2 Tumorigenic activity of total population, isolated CD44+ and CD44 EC fractions

From: Nanotechniques Inactivate Cancer Stem Cells

Groups

Introducible dose of EC cells

Administration of total population of EC cells

Administration of CD44+ EC cell fraction

Administration of CD44 EC cell fraction

Total number of EC cells in the peritoneal cavity (×107) when administering under various concentrations

3 × 106

35.80 ± 1.27

826.51 ± 6.53*

7.82 ± 0.94*

3 × 105

3.00 ± 0.25

65.00 ± 1.27*

3 × 104

13.50 ± 0.31

3 × 103

Number of animals with EC development to day 7 after administration of various concentrations of cells

3 × 106

10/10

10/10

5/10

3 × 105

5/10

9/10

0/10

3 × 104

0/10

3/10

0/10

3 × 103

0/10

0/10

0/10

  1. Note: number of animals with EC development was calculated by considering the number of animals with evident developed EC to day 7 (absolute number of cells in the peritoneal cavity was not less than 35.00 × 107), correlated to the number of animals in each group (n = 10)
  2. *Differences are statistically significant as compared with administration of total population of EC cells; (P < 0.05)

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