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Table 3 Change in composition and functional activity of in vivo cultured EC cells after pretreatment with hybrid nanocomplexes

From: Nanotechniques Inactivate Cancer Stem Cells

Index

Pre-treatment variants

Option 1

Option 2

Control

Concentration of cells with corresponding phenotype, %

CD44high

0.09 ± 0.01*

0.02 ± 0.001*, **

0.17 ± 0.03

CD44+CD24

0.75 ± 0.05*

0.40 ± 0.02*, **,

3.78 ± 0.51

CD44+CD24+

2.75 ± 0.28

9.77 ± 0.62*, **

2.89 ± 0.22

CD44CD24+

6.18 ± 0.32

7.85 ± 0.44*

5.33 ± 0.64

Sca-1+

81.82 ± 5.28

83.77 ± 5.73

90.32 ± 5.33

CD117+

5.04 ± 0.32

10.47 ± 0.83*,**

7.81 ± 0.83

CD44high/CD117+ ratio (rel. units)

0.018

0.002

0.02

TN (×107)

14.53 ± 0.72*

9.06 ± 0.25*,**

35.80 ± 2.27

Inhibition rate of EC growth (Ri) (%)

59.41 ± 3.45

74.70 ± 4.38**

  1. Note: number of animals with EC development was calculated by considering the number of animals with evident EC degree to day 7 (absolute number of cells in the peritoneal cavity was not less than 35.00 × 107), correlated to the number of animals in each group (n = 10); TN a total number of EC cells in peritoneal cavity (×107)
  2. *Differences are statistically significant as compared with administration of the control; **option 1 (P < 0.05)

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