Table 3 Change in composition and functional activity of in vivo cultured EC cells after pretreatment with hybrid nanocomplexes
Index | Pre-treatment variants | |||
---|---|---|---|---|
Option 1 | Option 2 | Control | ||
Concentration of cells with corresponding phenotype, % | CD44high | 0.09 ± 0.01* | 0.02 ± 0.001*, ** | 0.17 ± 0.03 |
CD44+CD24– | 0.75 ± 0.05* | 0.40 ± 0.02*, **, | 3.78 ± 0.51 | |
CD44+CD24+ | 2.75 ± 0.28 | 9.77 ± 0.62*, ** | 2.89 ± 0.22 | |
CD44–CD24+ | 6.18 ± 0.32 | 7.85 ± 0.44* | 5.33 ± 0.64 | |
Sca-1+ | 81.82 ± 5.28 | 83.77 ± 5.73 | 90.32 ± 5.33 | |
CD117+ | 5.04 ± 0.32 | 10.47 ± 0.83*,** | 7.81 ± 0.83 | |
CD44high/CD117+ ratio (rel. units) | 0.018 | 0.002 | 0.02 | |
TN (×107) | 14.53 ± 0.72* | 9.06 ± 0.25*,** | 35.80 ± 2.27 | |
Inhibition rate of EC growth (Ri) (%) | 59.41 ± 3.45 | 74.70 ± 4.38** | – |