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Table 3 The main plasma pharmacokinetic parameters of bufalin after intravenous administration of bufalin entity, bufalin-loaded liposomes, and bufalin-loaded PEGylated liposomes in rats (n = 6)

From: Improved Antitumor Efficacy and Pharmacokinetics of Bufalin via PEGylated Liposomes

Parameters (unit) Bufalin entity Bufalin-loaded liposomes Bufalin-loaded PEGylated liposomes
AUC(0–t) (ng/(mL min)) 25,012.0 ± 2246.3 57,137.5 ± 1453.1** 138,046.0 ± 2771.8**
AUC(0–∞) (ng/(mL min)) 25,334.3 ± 2243.9 57,751.9 ± 1554.0** 139,157.8 ± 2984.1**
MRT(0–t) (min) 29.74 ± 1.39 69.3 ± 2.0** 138.1 ± 3.3**
MRT(0–∞) (min) 33.3 ± 2.3 73.28 ± 2.8** 142.9 ± 3.7**
T 1/2z (min) 40.5 ± 10.6 54.4 ± 3.3* 87.8 ± 7.8**
V z/F (L/kg) 0.003 ± 0.001 0.001 ± 0.0008** 0.0002 ± 0.0004**
C max (ng/mL) 1326.6 ± 24.5 1254.0 ± 16.6** 1071.3 ± 36.3**
  1. AUC (0–t) area under the curve from 0 to t, AUC (0–∞) area under the curve from 0 to ∞, MRT (0–t) mean retention time from 0 to t, MRT (0–∞) mean retention time from 0 to ∞; T 1/2z half-life, V z/F volume of distribution, C max peak concentration
  2. *P < 0.05, **P < 0.01 compared with bufalin entity group