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Table 4 Comparison of the developed method of deposition of PPD membrane with previously reported methods

From: Improvement of amperometric transducer selectivity using nanosized phenylenediamine films

Optimal method of PD polymerization Type of electrode Optimal isomer of PD Duration of the electrode preparation Effectiveness of blocking properties Storage stability Biosensor application Ref.
CV (from − 0.3 V to +0.9 V vs. Ag/AgCl) Pd disk m-PD 48 min Full blocking of AA, cys, acetaminophen.
Small interference from UA
N/A N/A [8]
Constant potential (+0.7 V vs. Ag/AgCl) Ru-covered carbon fiber ME m-PD 45 min Full blocking of UA, cys, acetaminophen, DA.
Small interference from AA—addition of ascorbate oxidase to remove it
> 2 days Glucose, lactate and glutamate biosensors, in vivo analysis in rat brain [6]
Constant potential (+0.7 V vs. SCE) Pt–Ir cylinders ME o-PD 15 min Full blocking of AA > 7 days N/A [7]
(from −0.25 V to +0.9 V vs. SCE)
Glassy carbon electrode o-PD 15 min Full blocking of AA, UA and DA > 15 days N/A, H2O2 detection in human serum samples [9]
Constant potential (+0.7 V vs. Ag/AgCl) Pt cylinders ME o-PD 15 min Full blocking of AA N/A N/A [13]
(from 0 V to +0.9 V vs. Ag/AgCl)
Pt disk m-PD 6 min Full blocking of AA, cys, UA, DA > 8 days Human serum samples and cell lysate This work
  1. ME microelectrode, AA ascorbic acid, cys cysteine, DA dopamine, UA uric acid, N/A not applicable