Fig. 3

Cell uptake of the nanoparticles. a 6MP-AuNPs and 6MP-AuNPs-RDP solutions of 0.25 μg/mL were respectively adjusted to pH 7.4 and added into the cell media for a 30-min incubation. The particles were internalized into SH-SY5Y cells or precipitated on well bottoms. b Schematic diagram of 6MP- and fluorescence-labeled peptide-modified AuNP. After the SH-SY5Y cells were incubated with the particles for 2 h, images were taken (c) and fluorescence intensity (d) was measured. Data are presented as mean ± SEM. The values were averaged for four independent experiments. ^**p < 0.01 compared with the 6MP-AuNPs-SP-treated cells