A Comparative In Vivo Scrutiny of Biosynthesized Copper and Zinc Oxide Nanoparticles by Intraperitoneal and Intravenous Administration Routes in Rats

Table 4 Body weight changes for rat treated with Bio-CuNPs and Bio-ZnONPs through intraperitoneal route of administration

Days after injection	Group I: Bio-CuNPs’ body weight (g)			Group II: Bio-ZnONPs’ body weight (g)			Control
Days after injection	NOAEC	IC₅₀	TLC	NOAEC	IC₅₀	TLC	Body weight (g)
1	100 ± 5.2	100 ± 6.73	100 ± 8.3	100 ± 5.21	100 ± 5.26	100 ± 6.94	100 ± 5.23
2	100.2 ± 6.63	100 ± 7.99	100.5 ± 5.28	100.4 ± .6.54	100.25 ± 6.5	100 ± 6.32	102 ± 6.7
4	99.7 ± 6.94	102.6 ± 7.073	99.4 ± 7.83	101.7 ± 6.66	100.7 ± 6.3	99.8 ± 4.21	102 ± 7.84
6	98.4 ± 7.73	102.3 ± 9.093	99.2 ± 7.94	101.8 ± 7.21	99.7 ± 4.1	99.56 ± 3.75	105 ± 8.8
8	99.7 ± 5.45	100.2 ± 8.702	97.3 ± 5.45	102.2 ± 5.64	99.6 ± 3.93	98.6 ± 4.03	106 ± 7.32
10	100.8 ± 4.84	99.3 ± 5.88	97.6 ± 6.35	104.8 ± 8.21	100.67 ± 8.5	97.23 ± 3.2	106 ± 5.46
12	102.7 ± 6.33	99.3 ± 6.93	96.2 ± 7.44	106.2 ± 6.94	100.8 ± 7.3	96.8 ± 5.3	108 ± 6.94
14	100 ± 7.21	98 ± 7.3	96.3 ± 5.95	106.7 ± 7.74	98.4 ± 4.6	94.5 ± 6.86	108 ± 6.42
16	102 ± 6.42	101.5 ± 6.45	97.7 ± 6.83	107 ± 6.2	97.43 ± 3.4	96.6 ± 4.31	110 ± 5.67
18	104 ± 4.73	102.7 ± 8.32	98.3 ± 5.79	108.5 ± 8.05	98.7 ± 5.5	98.5 ± 5.94	110 ± 7.12
20	106 ± 5.88	104 ± 5.6	98.6 ± 4.67	110.2 ± 7.34	97.2 ± 5.3	96.7 ± 4.7	112 ± 5.09
22	105.4 ± 6.063	102.4 ± 9.5	99.2 ± 3.45	112.5 ± 6.21	100.3 ± 6.74	99.6 ± 4.43	114 ± 6.56
24	106.7 ± 7.83	103.8 ± 5.6	100 ± 5.23	112.6 ± 5.92	102.6 ± 7.2	99.7 ± 3.78	118 ± 7.58
26	107.3 ± 6.08	103 ± 5.7	100.5 ± .6.05	114.5 ± 7.12	103.23 ± 6.78	100.5 ± 5.34	119 ± 4.53
28	109.4 ± 5.73	105.7 ± 7.6	102.9 ± 6.85	117.8 ± 8.49	104.45 ± 5.54	99.8 ± 4.95	120 ± 6.25

All data are expressed in mean ± SD of the mean of the three independent experiments; each was carried out in triplicate, N = 6 rats per group