Toxicity Assessment of PEG-PCCL Nanoparticles and Preliminary Investigation on Its Anti-tumor Effect of Paclitaxel-Loading

Table 1 Effect of post-infusion with PEG-PCCL on the histopathological grade in 6 rabbits at 12 and 24 h

		Inflammatory cell infiltration				P value	Edema				P value	Thrombus				P value	Epidermal degeneration				P value
	Grade	0	1	2	3		0	1	2	3		0	1	2	3		0	1	2	3
Group	Control	6	0	0	0		4	2	0	0		6	0	0	0		5	1	0	0
	Post-infusion with PEG-PCCL (12 h)	5	1	0	0	N.S.	4	1	1	0	N.S.	6	0	0	0	N.S.	4	2	0	0	N.S.
	Post-infusion with PEG-PCCL (24 h)	5	1	0	0	N.S.	4	2	0	0	N.S.	6	0	0	0	N.S.	4	1	1	0	N.S.