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Fig. 4 | Nanoscale Research Letters

Fig. 4

From: Modified Fe3O4 Magnetic Nanoparticle Delivery of CpG Inhibits Tumor Growth and Spontaneous Pulmonary Metastases to Enhance Immunotherapy

Fig. 4

Antitumor ability of FeNP/CpG particles in vivo. a Treatment schedule of antitumor by FeNP/CpG particles both in C26 colon cancer and 4T1 breast cancer xenograft models through intratumoral injection in vivo. bd FeNP/CpG particle treatment inhibited the growth of 4T1 tumors. b Representative tumor growth curves of the 4T1 tumor model. c Average tumor weight. d Average lung tumor nodule in each group clearly showing lung metastasis after FeNP/CpG intratumoral injection. e, f Brightfield imaging and H&E staining of the lungs: e The number of visible lung metastases, arrows indicate lung metastases. f H&E staining of the lung metastasis. Scale bars, 100 μm for H&E staining. g, h FeNP/CpG particles significantly inhibited the growth of C26 xenograft tumors: e tumor growth curves of each group during the experiment and f average tumor weight. There were 10 mice in each group. g Tumor re-challenge experiment. i In C26 model, mice that were cured with FeNP/CpG treatment were re-challenged with 5 × 105 C26 (right flank) or 4T1 cells (left flank) s.c. into two separate sites on the opposite side of the flank without further treatment. Images shown are representative mice at 20 days after tumor re-challenge. All data were representative of three independent experiments, the mean ± SEM; *P < 0.05, *P < 0.01, and ***P < 0.001

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