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Table 3 Analysis of variance (ANOVA) for response quadratic surface model

From: Preparation of Glycyrrhetinic Acid Liposomes Using Lyophilization Monophase Solution Method: Preformulation, Optimization, and In Vitro Evaluation

Indexa

Sourceb

Sum of squares

Mean square

F value

P valuec

EE

Model

353.64

39.29

12.81

0.0014

X 1

145.78

145.78

47.54

0.0002

X 2

19.69

19.69

6.42

0.0390

X 3

0.024

0.024

7.89E-03

0.9317

X 1 X 2

24.65

24.65

8.04

0.0252

X 1 X 3

0.62

0.62

0.20

0.6655

X 2 X 3

8.47

8.47

2.76

0.1405

X 1 X 1

91.39

91.39

29.80

0.0009

X 2 X 2

43.35

43.35

14.14

0.0071

X 3 X 3

7.02

7.02

2.29

0.1740

MD

Model

576.73

64.08

1.90

0.2052

X 1

56.71

56.71

1.68

0.2361

X 2

5.61

5.61

0.17

0.6957

X 3

248.65

248.65

7.36

0.0300

X 1 X 2

17.22

17.22

0.51

0.4982

X 1 X 3

47.61

47.61

1.41

0.2738

X 2 X 3

21.16

21.16

0.63

0.4546

X 1 X 1

51.51

51.51

1.53

0.2567

X 2 X 2

0.27

0.27

7.95E-03

0.9314

X 3 X 3

119.28

119.28

3.53

0.1022

  1. aMD mean diameter, EE entrapment efficiency
  2. bX1 quantity of SPC, X2 quantity of cholesterol, X3 volume percentage of TBA
  3. cP value less than 0.05 were considered statistically significant

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