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Table 3 Screening of different cryoprotectants on the basis of mean PS and PDI

From: Lyophilized Hybrid Nanostructured Lipid Carriers to Enhance the Cellular Uptake of Verapamil: Statistical Optimization and In Vitro Evaluation

Cryoprotectants (Lipid:cryoprotectant) ratio Before lyophilization After lyophilization
PS (nm) PDI PS (nm) PDI
Mannitol 1:1 180.56 ± 3.53 0.575 ± 0.022 9153.57 ± 10,360.71 1 ± 0.00
Fructose 1:1 481.42 ± 41.78 0.941 ± 0.102
Sucrose 1:1 532.98 ± 231.80 1 ± 0.00
Trehalose 1:1 214.92 ± 3.75 0.554 ± 0.039
Lactose 1:1 2153.92 ± 1830.25 1 ± 0.00
  1. PS particle size, PDI polydispersity index