Account

Table 1 Cellular competition study of P1-Gd-LP, P2-Gd-LP, and P3-Gd-LP, with P1, P2, and P3 respectively added to inhibit receptors in the competition groups. The data of all experiments were expressed by the mean ± standard deviation (n = 5)

From: Dual integrin αvβ 3 and NRP-1-Targeting Paramagnetic Liposome for Tumor Early Detection in Magnetic Resonance Imaging

Gd concentration (mmol/l)	HUVEC				A549
	Gd-LP		P1-Com		Gd-LP		P1-Com
P1-Gd-LP	1.15 ± 0.04	P < 0.001	1.26 ± 0.10	P = 0.001	1.12 ± 0.06	P < 0.001	1.19 ± 0.08	P < 0.001
P1-Gd-LP	1.62 ± 0.16	P < 0.001	1.62 ± 0.16	P = 0.001	1.72 ± 0.07	P < 0.001	1.72 ± 0.07	P < 0.001
Gd-LP	–		1.26 ± 0.10	P = 0.227	–		1.19 ± 0.08	P = 0.029
Gd-LP	–		1.15 ± 0.04	P = 0.227	–		1.12 ± 0.0	P = 0.029
	Gd-LP		P2-Com		Gd-LP		P2-Com
P2-Gd-LP	0.95 ± 0.03	P < 0.001	1.05 ± 0.04	P < 0.001	0.85 ± 0.06	P = 0.001	0.90 ± 0.07	P = 0.007
P2-Gd-LP	1.24 ± 0.05	P < 0.001	1.24 ± 0.05	P < 0.001	1.03 ± 0.06	P = 0.001	1.03 ± 0.06	P = 0.007
Gd-LP	–		1.05 ± 0.04	P = 0.045	–		0.90 ± 0.07	P = 0.202
Gd-LP	–		0.95 ± 0.03	P = 0.045	–		0.85 ± 0.06	P = 0.202
	Gd-LP		P3-Com		Gd-LP		P3-Com
P3-Gd-LP	0.92 ± 0.04	P < 0.001	1.02 ± 0.06	P < 0.001	0.88 ± 0.04	P < 0.001	0.92 ± 0.06	P = 0.002
P3-Gd-LP	1.15 ± 0.4	P < 0.001	1.15 ± 0.4	P < 0.001	1.10 ± 0.10	P < 0.001	1.10 ± 0.10	P = 0.002
Gd-LP	–		1.02 ± 0.06	P = 0.075	–		0.92 ± 0.06	P = 0.401
Gd-LP	–		0.92 ± 0.04	P = 0.075	–		0.88 ± 0.04	P = 0.401

Back to article page