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Fig. 6 | Nanoscale Research Letters

Fig. 6

From: SPIO Enhance the Cross-Presentation and Migration of DCs and Anionic SPIO Influence the Nanoadjuvant Effects Related to Interleukin-1β

Fig. 6

Graphical abstract of SPIO as a nano-adjuvant for DCs. SPIO enhances the function of DCs by promoting the loading of DCs; thus, SPIO-labeled DCs can migrate to the ILNs active in an immune organ and may offer a new approach in cancer immunotherapy. Anionic-charged SPIOs activate protective IL-1β responses by triggering caspase-1 in DCs, thereby impairing antigen presentation to active T cells

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