Fig. 1

Schematic diagram of the designed nanoplatform and its mechanism of action. a the structure of MNP, and functionalization with anti-CHO antibody (NANOCHOAD), b strategies for penetration of the nanoplatform through BBB, c Crossing mechanism through the BBB of NANOCHOAD. d nanoconjugate anti-CHO-MNP targeting CHO deposits on amyloid plaques