Piperlongumine-Eluting Gastrointestinal Stent Using Reactive Oxygen Species-Sensitive Nanofiber Mats for Inhibition of Cholangiocarcinoma Cells

Table 3 IC₅₀ of PL itself and released PL from nanofiber mats against various CCA cells

	IC₅₀ (μg/mL)^a
	PL itself	PL released from nanofiber		PL released from nanofibers in the presence of H₂O₂
	PL itself	Day 5	Day 15	Day 5	Day 15
HuCC-T1	8.3	11.0	16.3	14.8	14.1
SNU1196	8.1	9.8	14.7	14.9	15.5
SNU478	9.2	11.3	14.1	14.2	–^b
SNU245	6.4	8.3	10.3	6.5	9.1

^a IC₅₀ values of PL released from nanofiber were estimated from cell viability curve in Fig. 4
^b -, not determined