Fig. 3

Time-dependent cellular uptake and tissue distribution. a The data on time-dependent cellular uptake are presented as the mean ± SD of three groups. b Comparison of the data on the biodistribution of ¹³¹I in the tumor and major organs of ATC tumor-bearing mice at 24 and 72 h after intratumoral injection of Na¹³¹I, ¹³¹I-BSA-MSNs, and ¹³¹I-BSA-MSNs-anti-VEGFR2. The tumor tissue radioactivity of anti-VEGFR2 targeted group at 24 and 72 h after intratumoral injection (32.2 ± 2.8% ID/g and 23.0 ± 1.8% ID/g, respectively) was significantly higher than that of non-targeted group (26.1 ± 2.5% ID/g and 12.3 ± 1.2% ID/g, respectively) (all P < 0.05). Data are also presented as the mean ± SD for the three groups