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Fig. 5 | Nanoscale Research Letters

Fig. 5

From: Antitumor Effect of 131I-Labeled Anti-VEGFR2 Targeted Mesoporous Silica Nanoparticles in Anaplastic Thyroid Cancer

Fig. 5

Histopathological analysis. a Histopathologic analysis of major organs of FRO ATC tumor-bearing mice after treatment with 131I-labeled nanoparticles. No significant pathological changes in the heart, liver, lung, and kidney were observed. b Pathologic examinations (H &E staining) and immunohistochemical analysis of tumors in mice. Large fragments from the degeneration and necrosis of tumor cells in the anti-VEGFR2-targeted group and small pieces of low density necrosis in the 131I-BSA-MSNs group are displayed. By contrast, only viable tumor cells were observed in the Na131I and saline groups. Photomicrograph from immunohistochemical analysis showed visible expression of VEGFR. Bar = 200 μm

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