Table 1 Distribution of C6 rat glioma cells in different phases of the cell cycle under treatment for 24 h with 4-thiazolidinone derivatives Les-3288 and Les-3833 in free form and in complex with polymeric nanocarrier (PNC)
Sample | Number of cells in each cell cycle phase, mean ± SD | |||
---|---|---|---|---|
Pre-G1 | G 1 | S | G2/M | |
Control | 3.52 ± 0.67 | 75.06 ± 0.57 | 11.61 ± 0.22 | 10.82 ± 1.21 |
PNC 0.1 μg/mL | 3.30 ± 0.44 | 76.03 ± 0.52 | 13.33 ± 0.41 | 8.81 ± 0.92 |
PNC 0.5 μg/mL | 5.78 ± 0.51 | 61.30 ± 0.50*** | 12.07 ± 0.12 | 16.06 ± 0.18 |
Les-3288 0.1 μg/mL | 2.81 ± 0.45 | 75.99 ± 0.06 | 12.01 ± 0.43 | 10.32 ± 1.10 |
Les-3288 0.5 μg/mL | 5.99 ± 0.54* | 63.33 ± 0.67*** | 16.09 ± 0.12*** | 15.19 ± 0.43*** |
Les-3288 + PNC 0.1 μg/mL | 3.27 ± 0.31 | 73.54 ± 0.39 | 12.48 ± 1.20 | 11.44 ± 0.40 |
Les-3288 + PNC 0.5 μg/mL | 24.89 ± 1.49●●● | 47.65 ± 0.34●●● | 9.77 ± 0.53●●● | 16.45 ± 0.16 |
Les-3833 0.1 μg/mL | 3.06 ± 0.45 | 72.99 ± 0.84* | 12.92 ± 1.11 | 12.07 ± 0.31 |
Les-3833 0.5 μg/mL | 2.88 ± 0.67 | 72.53 ± 1.09** | 13.23 ± 0.56 | 12.64 ± 0.41 |
Les-3833+PNC 0.1 μg/mL | 9.11 ± 0.53### | 54.86 ± 0.57### | 17.40 ± 0.61 | 19.55 ± 1.41# |
Les-3833+PNC 0.5 μg/mL | 18.69 ± 1.71§§§ | 53.42 ± 0.21§§§ | 12.30 ± 0.55 | 15.32 ± 1.91 |