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Table 1 Distribution of C6 rat glioma cells in different phases of the cell cycle under treatment for 24 h with 4-thiazolidinone derivatives Les-3288 and Les-3833 in free form and in complex with polymeric nanocarrier (PNC)

From: Enhanced Proapoptotic Effects of Water Dispersed Complexes of 4-Thiazolidinone-Based Chemotherapeutics with a PEG-Containing Polymeric Nanocarrier

Sample

Number of cells in each cell cycle phase, mean ± SD

 

Pre-G1

G 1

S

G2/M

Control

3.52 ± 0.67

75.06 ± 0.57

11.61 ± 0.22

10.82 ± 1.21

PNC 0.1 μg/mL

3.30 ± 0.44

76.03 ± 0.52

13.33 ± 0.41

8.81 ± 0.92

PNC 0.5 μg/mL

5.78 ± 0.51

61.30 ± 0.50***

12.07 ± 0.12

16.06 ± 0.18

Les-3288 0.1 μg/mL

2.81 ± 0.45

75.99 ± 0.06

12.01 ± 0.43

10.32 ± 1.10

Les-3288 0.5 μg/mL

5.99 ± 0.54*

63.33 ± 0.67***

16.09 ± 0.12***

15.19 ± 0.43***

Les-3288 + PNC

0.1 μg/mL

3.27 ± 0.31

73.54 ± 0.39

12.48 ± 1.20

11.44 ± 0.40

Les-3288 + PNC

0.5 μg/mL

24.89 ± 1.49●●●

47.65 ± 0.34●●●

9.77 ± 0.53●●●

16.45 ± 0.16

Les-3833 0.1 μg/mL

3.06 ± 0.45

72.99 ± 0.84*

12.92 ± 1.11

12.07 ± 0.31

Les-3833 0.5 μg/mL

2.88 ± 0.67

72.53 ± 1.09**

13.23 ± 0.56

12.64 ± 0.41

Les-3833+PNC

0.1 μg/mL

9.11 ± 0.53###

54.86 ± 0.57###

17.40 ± 0.61

19.55 ± 1.41#

Les-3833+PNC

0.5 μg/mL

18.69 ± 1.71§§§

53.42 ± 0.21§§§

12.30 ± 0.55

15.32 ± 1.91

  1. Data are presented as mean ± SD
  2. *P < 0.05 related to control, **P < 0.01 related to control, ***P < 0.001 related to control, ●●●P < 0.001 related to Les-3288, 0.5 μg/mL, #P < 0.01 related to Les-3833, 0.1 μg/mL, ###P < 0.001 related to Les-3833, 0.1 μg/mL, §P < 0.05 related to Les-3833, 0.5 mg/mL, §§§P < 0.001 related to Les-3833, 0.5 mg/mL

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