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Table 2 The percentages of rat glioma C6 cells for each level of genotoxicity after 3 h of treatment with the free form of compounds Les-3288 and Les-3833, and their complexes with the polymeric nanocarrier (PNC)

From: Enhanced Proapoptotic Effects of Water Dispersed Complexes of 4-Thiazolidinone-Based Chemotherapeutics with a PEG-Containing Polymeric Nanocarrier

Sample Comet class (% of cells) DI
0 1 2 3 4
Control 81.3 ± 0.5 18.6 ± 0.4     18.60 ± 0.35
Les-3288 81.3 ± 0.3 16.0 ± 0.2 2.6 ± 0.4    21.20 ± 0.52***
Les-3288+PNC 84.0 ± 0.1 12.0 ± 0.1 2.6 ± 0.4 1.3 ± 0.2   21.10 ± 0.23**
Les-3833 38.6 ± 0.3 60.0 ± 0.5 1.4 ± 0.2    62.80 ± 0.84***
Les-3833+PNC 8.0 ± 0.3 76.0 ± 2.9 13.3 ± 0.8 2.6 ± 0.3   110.40 ± 3.13***
PNC 84.0 ± 0.6 16.0 ± 0.1     16.00 ± 0.11
Dox 62.6 ± 0.4 36.0 ± 0.4    1.3±0.17 41.20 ± 0.40***
  1. Damage index (DI): **P ≤ 0.01, ***P < 0.001 compared with untreated control cells