Fig. 4
From: Cationic micelle-based siRNA delivery for efficient colon cancer gene therapy
Anticancer effects and safety of DMP/siRNA on C26 mouse xenograft model. a Tumor development curve, calculated by tumor volume. b Average weight of tumors in each group. Compared with other treatment groups, the DMP/siMcl1 group and DMP/ siBcl-xl group achieved a statistically significant reduction in tumor weight (***P, 0.001). c Representative images of tumors of C26 colon carcinoma. d Apoptosis in tumor tissues detected by TUNEL assay. e HE analysis of main organs from each treatment group in both models. No significantly pathological changes were observed in heart, liver, spleen, lung, or kidney