Table 1 Hydrodynamic diameters and polydispersity index (PDI) and zeta (z)-potential of the 40 and 80 nm bare and PC AuNP with cationic BPEI, anionic LA, and neutral PEG in a microsomal incubation buffer (100 mM phosphate buffer) at 0 min and 45 min at 37 °C. Data is mean ± S.D. (n = 5)
From: Impact of Gold Nanoparticles on Testosterone Metabolism in Human Liver Microsomes
AuNP size (nm) | Surface coatings | Hydrodynamic diameters (nm) | PDI | z-potential | |||
---|---|---|---|---|---|---|---|
0 min | 45 min | 0 min | 45 min | 0 min | 45 min | ||
40 | BPEI | 498.5 ± 25.4 | 807.6 ± 51.8*** | 0.38 ± 0.05 | 0.40 ± 0.04 | − 8.2 ± 2.6 | −18.0 ± 1.1** |
LA | 584.5 ± 12.7 | 816.4 ± 0.5** | 0.36 ± 0.04 | 0.38 ± 0.02 | −22.6 ± 1.8 | −21.6 ± 0.9 | |
PEG | 685.4 ± 13.5 | 715.2 ± 41.9 | 0.32 ± 0.02 | 0.43 ± 0.02** | − 7.6 ± 0.5 | − 9.1 ± 0.6** | |
PC LA | 165.5 ± 0.1 | 168.1 ± 0.1 | 0.48 ± 0.07 | 0.50 ± 0.13 | −11.5 ± 1.1 | − 11.8 ± 1.7 | |
PC PEG | 73.5 ± 0.02 | 77.3 ± 1.3** | 0.09 ± 0.02 | 0.18 ± 0.01*** | −9.5 ± 1.5 | − 11.8 ± 1.1 | |
80 | BPEI | 764.4 ± 14.6 | 925.9 ± 58.2** | 0.40 ± 0.06 | 0.42 ± 0.04 | −6.3 ± 0.6 | −12.7 ± 0.8*** |
LA | 835.0 ± 46.5 | 859.1 ± 63.1 | 0.45 ± 0.02 | 0.51 ± 0.06 | −29.9 ± 1.8 | − 29.5 ± 1.3 | |
PEG | 113.0 ± 0.60 | 111.4 ± 0.6 | 0.09 ± 0.01 | 0.11 ± 0.01 | −11.0 ± 1.3 | −12.3 ± 1.2 | |
PC LA | 133.2 ± 0.01 | 128.1 ± 0.02** | 0.10 ± 0.01 | 0.09 ± 0.02 | −12.0 ± 1.1 | −12.3 ± 0.8 | |
PC PEG | 126.5 ± 0.01 | 128.4 ± 1.6 | 0.08 ± 0.01 | 0.12 ± 0.01** | −8.7 ± 4.4 | −11.2 ± 1.9 |