Table 1 Data for plotting the isobole
DXR | LV | Additive effect, (Pd)D + (Pd)L | Addition dose, (DoseD + DoseL) (μM) | Dose pair, (DoseD,DoseL) (μM) | ||
|---|---|---|---|---|---|---|
Pd = 0.4865 − 0.2606 lgdose (R2 = 0.9529) | Pd = 1.092 − 0.05881 dose (R2 = 0.9808) | |||||
(1-Pd) C | DoseD (μM) | (1-Pd)L | DoseL (μM) | |||
0% | 0 | 50% | 10.066 | 50% | 10.066 | (0,10.066) |
10% | 0.0259 | 40% | 8.3659 | 50% | 8.3918 | (0.0259,8.3659) |
20% | 0.0627 | 30% | 6.6655 | 50% | 6.7282 | (0.0627,6.6655) |
30% | 0.1516 | 20% | 4.9651 | 50% | 5.1167 | (0.1516,4.9651) |
40% | 0.3668 | 10% | 3.2648 | 50% | 3.6316 | (0.3668,3.2648) |
50% | 0.8876 | 0% | 0 | 50% | 0.8876 | (0.8876,0) |