Table 1 DNA translocation speed with some DNA control method
From: Controlling DNA Translocation Through Solid-state Nanopores
Control method | Advantages | Disadvantages | DNA translocation speed (bp/ms) |
|---|---|---|---|
Two nanopores system | Continuous collection of signals, high signal-to-noise ratio, low cost | Difficulty of mass-controlled manufacturing | ~ 1429 [37] |
Optical trap nanopore | Label-free, parallel detection | Difficulty of mass-controlled manufacturing | — |
Optical tweezers | Three-dimensional control | Cannot realize parallel detection, the heating impact | ~ 150 [52] |
Magnetic tweezers | Massively parallel detection | Force hysteresis | ~ 10 [49] |
AFM | Easy to control with less than 10 nm resolution | Effect of probe on nanopores | ~ 0.06 [50] |
TFFS | Faster scan motion, high force sensitivity | Effect of probe on nanopores | ~ 1 [57] ~ 10 [51] |
Si probe | No need for nanopores addressing | Adjacent DNA affects accuracy | ~ 0.1 [32] |