Table 3 Non-compartmental model of pharmacokinetic parameters of Caelyx® and ED-lip administrated i.v. in mice at the single dose of 10 mg/kg
t½ (h) | Tmax (h) | Cmax (μg/ml) | AUC0-t (μg/ml*h) | AUMC (μg/ml*h2) | MRT (h) | Cl (mg/kg)/(μg/ml)/h) | Vd (mg/kg)/(μg/ml) | |
|---|---|---|---|---|---|---|---|---|
Caelyx® | 39.3 | 3 | 150.1 | 4142 | 258110 | 47.6 | 0.0018 | 0.087 |
ED-lip | 34.2 | 3 | 136.7 | 3926 | 211668 | 42.9 | 0.002 | 0.087 |