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Fig. 3 | Nanoscale Research Letters

Fig. 3

From: Reactive Oxygen Species-Related Nanoparticle Toxicity in the Biomedical Field

Fig. 3

Cellular events induced by NPs. NPs contribute to the destruction of the cell membrane and to lipid peroxidation. The lysosomal membrane is destroyed by NPs and results in the release of their contents. The mitochondrial membrane is damaged by NPs, leading to content release. NPs reduce the generation of ATP and increase the production of ROS. The ROS induced by NPs results in the mistranslation of RNA. NPs prevent the binding of tRNA to the ribosome. The ROS induced by NPs result in the polymerization of proteins and DNA. The ROS induced by NPs leads to DNA mutations The nuclear membrane is destroyed by NPs, resulting in the release of its contents

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