Fig. 2

Downregulated MALAT1 represses blood pressure, the expression of ET-1, vWF, and MMP-9, as well as the apoptotic index of vascular endothelial cells of rats with IA. a ET-1 expression in serum of rats by ELISA. b vWF expression in serum of rats by ELISA. c Pathological changes of IA tissues in rats observed by HE staining. d The ultrastructure of IA tissues in rats observed by a transmission electron microscope. e Apoptosis of vascular endothelial cells by TUNEL staining. f Vascular endothelial cell apoptotic index of rats. g MALAT1, miR-143, and VEGFA mRNA expression in IA tissues of rats by RT-qPCR. h VEGFA, MMP-9, and vWF protein expression in IA tissues of rats by western blot analysis. * P < 0.05 vs. the sh-NC group, # P < 0.05 vs. the Oe-NC group. Measurement data were depicted as mean ± standard deviation, and comparisons among multiple groups were assessed by one-way analysis of variance followed with Tukey’s multiple comparisons test