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Fig. 6 | Nanoscale Research Letters

Fig. 6

From: Gint4.T-Modified DNA Tetrahedrons Loaded with Doxorubicin Inhibits Glioma Cell Proliferation by Targeting PDGFRβ

Fig. 6

a Cytotoxicity of DOX, the DOX@TDN, and the DOX@Apt-TDN at various concentrations. The inhibition rate of the U87MG cells was significantly increased with increasing DOX concentration, but the DOX@TDN and DOX@Apt-TDN groups exhibited significantly increased cytotoxicity compared with the DOX group. The cell inhibition rate of the DOX@Apt-TDN group was also significantly higher than that of the DOX@TDN group (compared to DOX, **p < 0.05; compared to DOX, ***p < 0.01; compared to DOX@Apt-TDN, #p < 0.05). b Apoptosis of U87MG cells after incubation with PBS, DOX, the DOX@TDN, and the DOX@Apt-TDN for 24 h. c Flow cytometry histograms of the U87MG cell cycle after incubation with PBS, DOX, the DOX@TDN, and the DOX@Apt-TDN for 24 h (compared to control, **p < 0.05; compared to control, ***p < 0.01; compared to DOX@Apt-TDN, #p < 0.01)

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