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Fig. 3 | Nanoscale Research Letters

Fig. 3

From: M1 Macrophage-Derived Exosomal MicroRNA-326 Suppresses Hepatocellular Carcinoma Cell Progression Via Mediating NF-κB Signaling Pathway

Fig. 3

M1 macrophage exosomal miR-326 inhibits cell proliferation and colony formation in HCC cells. a MTT assay detected the effect of transfection of miR-326 mimic on the proliferation of HepG2 cells. b MTT assay detected the effect of transfection of miR-326 inhibitor on the proliferation of SMMC-7721 cells. c MTT assay detected the effect of co-culture with miR-326 mimic-transfected M1 macrophage-derived exosomes on the proliferation of HepG2 cells. d MTT assay detected the effect of co-culture with miR-326 inhibitor-transfected M1 macrophage-derived exosomes on the proliferation of SMMC-7721 cells. e Colony formation assay detected the effect of transfection of miR-326 mimic on the colony formation ability of HepG2 cells. f Colony numbers of HepG2 cells. g Colony formation assay detected the effect of transfection of miR-326 inhibitor on the colony formation ability of SMMC-7721 cells. h Colony numbers of SMMC-7721 cells. i Colony formation assay detected the effect of co-culture with miR-326 mimic-transfected M1 macrophage-derived exosomes on the colony formation ability of HepG2 cells. j Colony numbers of HepG2 cells treated with exosomes. k Colony formation assay detected the effect of co-culture of miR-326 inhibitor-transfected M1 macrophage-derived exosomes on the colony formation ability of SMMC-7721 cells. l Colony numbers of SMMC-7721 cells treated with exosomes. In panel a and f, *P < 0.05 versus the NC-mimic group; In panel b and h, *P < 0.05 versus the NC-inhibitor group; In panel c and j, *P < 0.05 versus the control group, #P < 0.05 versus the Exo-NC-mimic group; In panel d and l, *P < 0.05 versus the control group, #P < 0.05 versus the Exo-NC-inhibitor group. Measurement data were depicted as mean ± standard deviation (N = 3), comparisons among multiple groups were conducted by one-way analysis of variance

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