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Fig. 4 | Nanoscale Research Letters

Fig. 4

From: RETRACTED ARTICLE: SOX2 Regulates lncRNA CCAT1/MicroRNA-185-3p/FOXP3 Axis to Affect the Proliferation and Self-Renewal of Cervical Cancer Stem Cells

Fig. 4

Overexpressed miR-185-3p suppresses proliferation, migration, invasion and sphere formation rate and increases apoptosis of CD44+HeLa cells. a CCK-8 assay tested cell growth curve in cells treated with miR-185-3p mimic. b Flow cytometry detected cell apoptosis in cells treated with miR-185-3p mimic. c Comparison of cell apoptosis rate in cells treated with miR-185-3p mimic. d Cell migration in cells treated with miR-185-3p mimic tested by scratch test. e Comparison of cell migration in cells treated with miR-185-3p mimic. f Detection of invasion ability of cells treated with miR-185-3p mimic by Transwell assay. g Comparison of the invasion ability of cells treated with miR-185-3p mimic. h Sphere-forming experiment tested self-renewal capacity in cells treated with miR-185-3p mimic. i Comparison of sphere formation rate in cells treated with miR-185-3p mimic. a p < 0.05 vs. the sh-SOX2 NC group. b p < 0.05 vs. the sh-CCAT1 NC group. c p < 0.05 vs. the mimic NC group. d p < 0.05 vs. the sh-CCAT1 + inhibitor NC group. Measurement data were depicted as mean ± standard deviation, and comparisons among multiple groups were assessed by one-way ANOVA followed by Tukey’s post hoc test

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