Fig. 6

Effects of Au@Ag NR on the cell cycle and apoptosis. Effects of Au@Ag NR on cell cycle (a, b) and apoptosis (c, d) after exposed for 24 h and 72 h, respectively; the representative data of expression levels of p53 and p21 in HepaRG cells of different groups (e, f Lane 1: vehicle control; Lane 2: Au NR; Lane 3: Au@Ag NR + NAC; Lane 4: Au@Ag NR 20 μg mL⁻¹; Lane 5: Au@Ag NR 4 μg mL⁻¹; Lane 6:Au@Ag NR 0.8 μg mL⁻¹); the averaged relative expression level of p53 and p21 to β-actin in different groups was summarized in (g, f).^*P < 0.05 versus vehicle control; ^aP < 0.05 versus Au NR