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Fig. 6 | Nanoscale Research Letters

Fig. 6

From: Nanodetection of Head and Neck Cancer on Titanium Oxide Sensing Surface

Fig. 6

Comparison of current changes with different concentrations of SCC-Ag on antibody- and GNS antibody-modified surfaces. a Linear regression graph for the limit of detection of SCC-Ag. With antibody (red line) and with GNS antibody (blue line) are displayed. The limit of detection was found as 10 fM with GNS antibody and 100 fM with only antibody. b Current changes with SCC-Ag and antibody interaction. With all the concentrations, a higher level of current changes was found on GNS antibody surface. A linear sweep voltage of 0 to 2 V at 0.01 V step voltage was followed for the measurements. Error bar indicates the averaged values from triplicates (n = 3) with the standard deviations are in the range of ± 0.1 to 0.15 × 10−9 A. The limit of detection (LOD) was considered the lowest concentration of an analyte (from the calibration line at low concentrations) against the background signal (S/N = 3:1), in other words, LOD = standard deviation of the baseline + 3σ

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