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Fig. 5 | Nanoscale Research Letters

Fig. 5

From: RETRACTED ARTICLE: The PI3K/mTOR dual inhibitor BEZ235 nanoparticles improve radiosensitization of hepatoma cells through apoptosis and regulation DNA repair pathway

Fig. 5

BEZ235 and NP-BEZ235-Ab enhance low-dose γ-ray-induced DNA fragmentation and inhibit the repair of damaged DNA. Immunofluorescence staining for γH2AX phosphorylation (DSB) in HepG2 cells after γ-ray or in combination with BEZ235 or NP-BEZ235-Ab. There was almost no DSB in the control group or BEZ235 group. However, the number of DSB in the nucleus increased after γ-ray irradiation, and the DSB level in the BEZ235 or NP-BEZ235-Ab combined γ-ray irradiation group were significantly higher than that in the single γ-ray group, suggesting that BEZ235 had increased radiosensitivity. Green, γ H2AX foci; blue, 4′,6-diamidino-2-phenylindole (DAPI)

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