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Nanoscale Research Letters
Fig. 6 | Nanoscale Research Letters

Fig. 6

From: RETRACTED ARTICLE: The PI3K/mTOR dual inhibitor BEZ235 nanoparticles improve radiosensitization of hepatoma cells through apoptosis and regulation DNA repair pathway

Fig. 6

Effect and mechanism of NP-BEZ235-Ab enhancing radiosensitivity. a After 4.0 Gy γ-ray irradiation, the γH2AX focus level in the nucleus increased significantly within 24 h and did not decrease significantly through 72 h. However, in the NP-BEZ235-Ab group combined with 4.0 Gy for 48 h, the nucleus began to condense; after 72 h, there was obvious nuclear pyknosis of cells treated with NP-BEZ235-Ab and radiation. b Expression of RAD51 and pATM in cells of different groups. c Expression levels of pBRCA1, RAD51, and pATM in different groups. d Schematic diagram of the mechanism of NP-BEZ235-Ab enhancing radiosensitivity

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