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Fig. 9 | Nanoscale Research Letters

Fig. 9

From: RETRACTED ARTICLE: The PI3K/mTOR dual inhibitor BEZ235 nanoparticles improve radiosensitization of hepatoma cells through apoptosis and regulation DNA repair pathway

Fig. 9

The role of NP-BEZ235-Ab in apoptosis-related proteins in each HepG2 cells. a Western blots of cellular extracts from HepG2 cell line in each group. Lysates were probed with antibodies against pDNA-PKcs, γH2AX, the cleaved form of caspase 3, and PARP. b Protein levels of γH2AX, the cleaved form of caspase 3, and PARP in the groups. c Diagram of the hypothetical effects of NP-BEZ235-Ab on the apoptosis and proliferation in HepG2 cells. Each value represents the mean ± SD of three independent experiments. *p < 0.05, **p < 0.01 versus control group. # p < 0.05, ## p < 0.01 versus γ-ray or BEZ235 group. + p < 0.05, ++ p < 0.01 versus NP-BEZ235-Ab or BEZ235 + γ-ray

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