Fig. 2

Inhibition of either HDAC1 or miR-124-5p increases weight and improves learning and memory abilities of depressed rats. a Effects of inhibition with HDAC1 or miR-124-5p on the body weight of depressed rats; b SPP before and after inhibition with HDAC1 or miR-124-5p; c Frequency of crossing the gird in OFT before and after inhibition with HDAC1 or miR-124-5p; d Incidence of rearing in OFT before and after inhibition with HDAC1 or miR-124-5p; e Escape latency in MWM test before and after inhibition with HDAC1 or miR-124-5p; f Space exploration time in MWM test before and after inhibition with HDAC1 or miR-124-5p; n = 10; a P < 0.05 compared with the normal group; b P < 0.05 compared with the sh-NC group; c P < 0.05 compared with the anti-miR-NC group. Comparisons among multiple groups were evaluated by one-way ANOVA, and pairwise comparisons by Tukey’s post hoc test