Fig. 1

Characterization of PLGA particles. Fluorescence micrographs show the different sizes (a 100 nm, b 500 nm, and c 1 µm) of PLGA particles. Those particles can be detected under Olympus Optical Microscopy exhibiting relative uniform particle size distributions in water suspension. Dynamic light scattering (DLS) measurements display the size distribution weighted by volume for 100 nm (d), 500 (e), 1 µm (f) PLGA particles. Despite a small part of particle aggregation (smaller peaks: 3–4%) in 100 nm and 1 µm PLGA suspensions, the overall particle size distribution is quite homogeneous because of the narrow main peak