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Fig. 3 | Nanoscale Research Letters

Fig. 3

From: Restored microRNA-326-5p Inhibits Neuronal Apoptosis and Attenuates Mitochondrial Damage via Suppressing STAT3 in Cerebral Ischemia/Reperfusion Injury

Fig. 3

Up-regulation of miR-326-5p or down-regulation of STAT3 impedes pathological damage of cortical neurons and inhibits apoptosis in rats with CI/RI. a Pathological damage of brain tissues in MCAO rats observed by HE staining (scale bar: 50 μm); b The number of intact neurons of MCAO rat brain tissues after up-regulating miR-326-5p or down-regulating STAT3; c Neuronal apoptosis in MCAO rat brain tissues detected by TUNEL staining (scale bar: 50 μm); d TUNEL-positive rates in MCAO rat brain tissues after up-regulating miR-326-5p or down-regulating STAT3; e Bcl-2 and Bax mRNA expression in MCAO rat brain tissues after up-regulating miR-326-5p or down-regulating STAT3; *P < 0.05 compared with the sham group; #P < 0.05 compared with the NC group; &P < 0.05 compared with the miR-326-5p agomir group

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