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Fig. 5 | Nanoscale Research Letters

Fig. 5

From: Restored microRNA-326-5p Inhibits Neuronal Apoptosis and Attenuates Mitochondrial Damage via Suppressing STAT3 in Cerebral Ischemia/Reperfusion Injury

Fig. 5

miR-326-5p targets STAT3. a miR-326-5p and STAT3 mRNA expression in OGD-treated cortical neurons in vitro; b, c STAT3 protein expression in OGD-treated cortical neurons in vitro; d miR-326-5p and STAT3 mRNA expression in MCAO rat brain tissues; e, f STAT3 protein expression in MCAO rat brain tissues; g Predicted binding site of miR-326-5p and STAT3 by bioinformatics software; h The targeting relationship between miR-326-5p and STAT3 validated by dual luciferase reporter gene assay; In Figure ac, *P < 0.05 compared with the control group; #P < 0.05 compared with the NC group; &P < 0.05 compared with the miR-326-5p agomir group. In Figure df, *P < 0.05 compared with the sham group; #P < 0.05 compared with the NC group; &P < 0.05 compared with the miR-326-5p agomir group

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