Fig. 3

Restored miR-499-5p or depleted Sox6 reduces TUNEL positive cells, Caspase-3 and Caspase-9 protein expression in lung tissues of sepsis-induced lung injury mice. a TUNEL positive cells in lung tissues of mice. b Number of TUNEL positive cells in lung tissues of mice. c Immunohistochemistry of Caspase-3 and Caspase-9 in lung tissue of mice; d Mean OD value of Caspase-3 and Caspase-9 in lung tissue of mice. e Protein bands of Caspase-3 and Caspase-9 in lung tissues of mice. f Caspase-3 and Caspase-9 protein expression in lung tissues of mice in each group. (a) P < 0.05 versus the sham group. (b) P < 0.05 versus the agomir NC group. (c) P < 0.05 versus the si-NC group. (d) P < 0.05 versus the miR-499-5p agomir + oe-NC group. Measurement data were depicted as mean ± standard deviation, and data were assessed by one-way ANOVA followed by Tukey’s post hoc test