Table 1 Liposomal drugs nanoparticles officially approved for various cancers treatment
From: Liposomal Nanomedicine: Applications for Drug Delivery in Cancer Therapy
Product commercial name | Active therapeutic agent | Liposomal nanoparticle platform | Drug category | Indication | Main composition of liposome | Type of infusion | Status | References |
|---|---|---|---|---|---|---|---|---|
AmbiSome | Amphotericin B | PEGylated liposome | Antifungal drug | Aspergillosis Cryptococcosis candidiasis | HSPC, DSPG and cholesterol | I.V | Approved | |
DepoDur | Morphine sulphate | Extended-Release Liposome | analgesic drug | General pain reduction | DOPC, DPPG, cholesterol and triolein | Epidural | Approved | |
Inflexal | Inactivated hemagglutinin of influenza virus strains A and B | Liposomes | Flu vaccines | Prevention of influenza disease | DSPC and cholesterol | I.M | Approved | |
DaunoXome | Daunorubicin citrate | Conventional liposome | anthracyline antitumor antibiotic | Blood cancer HIV-related Kaposi sarcoma | DSPC and cholesterol | I.V | Approved | |
Depocyt | Cytarabine | Conventional liposome | Antimetabolites chemotherapy medication | Acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL) | DOPC, DPPG, cholesterol and triolein | Spinal | Approved | |
Doxil | Doxorubicin | PEGylated liposome | Anthracyclines chemotherapy drugs | Ovarian and breast cancer, HIV-related Kaposi sarcoma, multiple myeloma | HSPC, cholesterol and DSPE-PEG2000 | I.V | Approved | |
Epaxal | Inactivated hepatitis A virus (strain RG-SB) | Liposomes | HAV vaccines | Prevention of Hepatitis A virus | DOPC and DOPE | I.M | Approved | |
Visudyne | Verteporfin | Conventional liposome | Photosensitizing agents | PDT sensitizer,pathologic myopia, ocular histoplasmosis | EPG and DMPC | I.V | Approved | |
Mepact | Muramyl tripeptide phosphatidylethanolamine | Conventional liposome | Immunomodulator antitumor compound | Solid tumors chemotherapy | DOPS and POPC | I.V | Approved | |
Nyotran | Nystatin | Conventional liposome | Polyenes antifungal liposomes | Systemic fungal infections | DMPC, DMPG, and cholesterol | I.V | Terminated | |
Onivyde or MM-398 | Irinotecan | PEGylated liposome | Topoisomerase I inhibitors antineoplastic medications | Post-gemcitabine metastatic Pancreatic cancer | DSPC,MPEG-2000:DSPE | I.V | Approved | |
liposomal bortezomib | Bortezomib | PEGylated liposome | Antineoplastic agents | Multiple myeloma | DPPC, MPEG2000-DSP, cholesterol | I.V or S.C | Approved | |
Marqibo | Vincristine | PEGylated liposome/ conventional liposome | Anti-malignant agents | Philadelphia chromosome-negative acute lymphoblastic leukemia | Sphingomyelin, cholesterol | I.V | Approved |