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Fig. 5 | Nanoscale Research Letters

Fig. 5

From: CoFe2O4-Quantum Dots for Synergistic Photothermal/Photodynamic Therapy of Non-small-Cell Lung Cancer Via Triggering Apoptosis by Regulating PI3K/AKT Pathway

Fig. 5

The combination of CoFe2O4-QDs and NIR induces ROS generation through regulating PI3K/AKT pathway. a, b NCI-H460 and A549 NSCLCs were treated with the CoFe2O4-QDs and NIR laser with or without NAC for 5 min. The ROS level was detected by FACS and the mean fluorescent intensity was quantified, respectively. The data were shown as mean ± SD, N = 3. **P < 0.01. c, d The protein level of P-PI3K and P-AKT was determined by Western blot analysis. Representative images are shown, N = 3

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