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Table 2 Nanoparticle-mediated drug delivery studies for neurodegenerative diseases using zebrafish

From: Zebrafish: A Promising Real-Time Model System for Nanotechnology-Mediated Neurospecific Drug Delivery

NP used

Insight

References

PEGylated and non-targeted NPs

Modulation of surface PEG chain lengths and NP size impacts endocytosis across the BBB and brain bioavailability of the NPs. This holds immense scope for future research in treating neurodegenerative diseases

[90]

SiNP

Evaluation of the neurotoxic effects of SiNP reveals its potential to cause PD

[211]

SiO2

Silicon oxide nanoparticles cause depression and anxiety and were used to create Parkinson’s like condition in adult zebrafish

[212, 213]

BmE-PtNPs

Bacopa monnieri Phytochemicals-mediated synthesis of platinum nanoparticles has neuroprotective effects in MPTP model of Parkinson’s disease

[214]

NP based strategy

The study evaluates the BBB penetration ability and bioavailability of several upconversion NPs in cell culture and zebrafish models

[215]

TiO2

Exposure to TiO2 NPs induces neurotoxicity and Parkinsonism in zebrafish larvae and PC12 cells

[216]

Au

Gold nanoparticle coupled with chaperone inhibits amyloid fibrils and ameliorates cognition in Zebrafish

[217]

  1. A list of studies on neurodegenerative diseases using nanoparticles in zebrafish

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