Table 2 Nanoparticle-mediated drug delivery studies for neurodegenerative diseases using zebrafish
NP used | Insight | References |
---|---|---|
PEGylated and non-targeted NPs | Modulation of surface PEG chain lengths and NP size impacts endocytosis across the BBB and brain bioavailability of the NPs. This holds immense scope for future research in treating neurodegenerative diseases | [90] |
SiNP | Evaluation of the neurotoxic effects of SiNP reveals its potential to cause PD | [211] |
SiO2 | Silicon oxide nanoparticles cause depression and anxiety and were used to create Parkinson’s like condition in adult zebrafish | |
BmE-PtNPs | Bacopa monnieri Phytochemicals-mediated synthesis of platinum nanoparticles has neuroprotective effects in MPTP model of Parkinson’s disease | [214] |
NP based strategy | The study evaluates the BBB penetration ability and bioavailability of several upconversion NPs in cell culture and zebrafish models | [215] |
TiO2 | Exposure to TiO2 NPs induces neurotoxicity and Parkinsonism in zebrafish larvae and PC12 cells | [216] |
Au | Gold nanoparticle coupled with chaperone inhibits amyloid fibrils and ameliorates cognition in Zebrafish | [217] |