Fig. 5
From: Tuning the Toxicity of Reactive Oxygen Species into Advanced Tumor Therapy
a A diagram of Fe5C2@Fe3O4 NPs for pH-responsive Fe2+ releasing, ROS generation and T2/T1 signal conversion. b pH-dependent MRI model switching of PEG/Fe5C2@Fe3O4 nanoparticles. c Schematic illustration for the underlying material chemistry and therapeutic concept: MOF (Fe) catalyzes Fenton-like reactions in cancer cells to convert the intrinsic nontoxic H2O2 into highly oxidative ·OH, which attacks and inactivates ambient protein and organelles and leads to their aberrant accumulation. d Schematic of the synthetic procedure and hypoxia-responsive copper metal–organic frameworks nanosystem for improved cancer therapy [54, 55, 65]