Fig. 4

Effects of depletion of miR-342-5p or restoration of Wnt3a on lipid and collagen content in aortic plaque of ApoE^−/− mice. A Results of aortic HE staining in mice (scale bar: 50 μm). B Comparison of aortic plaque area in each group of mice. C Results of aortic Oil Red O staining in all groups of mice (scale bar: 100 μm). D Comparison of lipid content in aortic tissue of mice. E Results of aortic Sirius red staining in each group of mice (scale bar: 50 μm). F Comparison of collagen contents in aortic tissues of mice. n = 12. ^#P < 0.05 vs. the NC group. & P < 0.05 vs. the miR-342-5p agomir group. Measurement data were indicated as mean ± standard deviation. Comparisons among multiple groups were assessed by one-way ANOVA followed by Tukey’s multiple comparisons test. AS, atherosclerosis; NC, negative control